Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllPTEN,atumorsuppressor,hasbeenimplicatedinalargenumberofhumantumorsandisconservedfromhumanstoworms.CharacterizationofPTENproteinshowedthatitisaphosphatasethatactsonproteinsandon3-phosphorylatedphosphoinositides,andcanthereforemodulatesignaltransductionpathwaysthatinvolvelipidsecondmessengers.Recentresultsindicatethatatleastpartofitsroleistoregulatetheactivityoftheserine/threoninekinaseAKT/PKB,andthusinfluencecellsurvivalsignaling.
References:
1.DegradationofC-terminaltruncatedalphaA-crystallinsbytheubiquitin-proteasomepathway. InvestOphthalmolVisSci2007Sep;48(9):4200-8
2.Ubiquitincarboxyl-terminalhydrolaseL1,anoveldeubiquitinatingenzymeinthevasculature,attenuatesNF-kappaBactivation. ArteriosclerThrombVascBiol2007Oct;27(10):2184-90
3.GlobalchangestotheubiquitinsysteminHuntington"sdisease. Nature2007Aug9;448(7154):704-8
4.Structuralbasisforubiquitin-mediateddimerizationandactivationoftheubiquitinproteinligaseCbl-b. MolCell2007Aug3;27(3):474-85
5.APC/C(Cdc20)controlstheubiquitin-mediateddegradationofp21inprometaphase. MolCell2007Aug3;27(3):462-73
6.TheadaptormoleculeCIN85regulatesSyktyrosinekinaselevelbyactivatingtheubiquitin-proteasomedegradationpathway. JImmunol2007Aug15;179(4):2089-96
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