请使用支持JavaScript的浏览器!
主营:神经科学、干细胞以及再生医学研究试剂
℡ 4000-520-616
℡ 4000-520-616
Neuromics/Cyckin-C (CCNC)/PR27045-2/2 ug
产品编号:PR27045-2
市  场 价:¥2160.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$108.00
品      牌: Neuromics
公      司:Neuromics
公司分类:
Neuromics/Cyckin-C (CCNC)/PR27045-2/2 ug
商品介绍

Type:Protein

 

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Picture
rCCNC(cyclinC)isamemberofthecyclinfamilyofproteins.Thisproteininteractswithcyclin-dependentkinase8(CDK8)andinducesthephophorylationofthecarboxy-terminaldomainofthelargesubunitofRNApolymeraseII.ThelevelofmRNAsforthisproteinpeaksintheG1phaseofthecellcycle.Ithasbeenshownthatanon-cdk8-associatedcellularpoolofCCNCcombineswithcdk3tostimulatepRbphosphorylationatS807/811duringtheG0/G1transition,andthatthisphosphorylationisrequiredforcellstoexitGOefficiently.OtherresultshaveshownthatamarkedelevatedimmunoreactivityofCCNCwasfoundbothinneuronsandastrocytesinAlzheimer"sdisease(AD).IncreasedlevelsofCCNCRNAweredetectedbyribonucleaseprotectionassay(RPA)insevereADcasesandcolocalizationofCCNCanditspreferredbindingpartner,CDK8,wasonlyobservedinastrocytesbutnotinneurons.
RecombinantCNCCisexpressedinE.coliasafull-lengthproteinfusedtoaproprietary16-Kdtag(a6xHistagislocatedattheveryN-terminalend).

Image:CNCCStructureandSequence.

Applications:

RecombinanthumanCNCCcanbeuseddirectlyasapositivecontrolinWesternblotting,ELISA,immunoprecipitationandotherimmunologicalexperiments.TheBIOLOGicalactivityofthisproducthasnotyetbeentested.

References:

1.GeneExpressionsSpecificallyDetectedinMotorNeurons(Dynactin1,EarlyGrowthResponse3,Acetyl-CoATransporter,DeathReceptor5,andCyclinC)DifferentiallyCorrelatetoPathologicMarkersinSporADIcAmyotrophicLateralSclerosis. JNeuropatholExpNeurol2007Jul;66(7):617-627.
2.TwoisoformsofthehumancyclinCgeneareexpresseddifferentiallysuggestingthattheymayhavedistinctfunctions. ActaBiolHung2007Mar;58(1):133-7.
3.OsmosensitivegeneexpressionoftaurinetransporterandcyclinCinembryonicfibroblastcells. AdvExpMedBiol2006;583:49-57.
4.Highlyfrequentalleliclossofchromosome6q16-23inosteosarcoma:involvementofcyclinCinosteosarcoma. IntJMolMed2006Dec;18(6):1153-8.
5.RegulationoftheoxidativestressresponsethroughSlt2p-dependentdestructionofcyclinCinSaccharomycescerevisiae. Genetics2006Mar;172(3):1477-86.
6.[InfluenceofaerosolsontheexpressionofcyclinB1,cyclinCandproliferatingcellnuclearantigeninwoundtissuehealingofburnedratmodels] ZhonghuaWaiKeZaZhi2005Oct1;43(19):1280-3. 

品牌介绍

Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。

Neuromics因为是由一批顶尖的学术和商业实验室挑选,试验和创新他们的 试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从 以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。


自营商城图标
厂家直采
全球直采 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔