Type:MouseIgG
Applications:IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
SuperoxideDismutases(SODs),originallyidentifiedasIndophenoloxidases(IPOs),areenzymesthatcatalyzetheconversionofnaturally-occuringbutharmfulsuperoxiderADIcalsintomolecularoxygenandhydrogenperoxide.SuperoxideDismutases2,SOD2,alsoknownasManganese(Mn)SOD,mitochondrialSODandIPO-B,isanintramitochondrial22kDahomotetramer.EachSOD2monomerbindsoneMn2+ion.ThreeisozymesofSODhavebeenidentifiedandarefunctionallyrelatedbuthaveverymodestsequencehomology.SOD2sharesonly23and17%sequenceidentitywithSOD1andSOD3,respectively.
Image:WesternblotdetectionofSOD2.RecombinanthumanSOD1,SOD2,andSOD3(1ng)andlysatesfromhumanMCF-7,mouseNIH-3T3andratL6cellswereresolvedbySDS-PAGE,transferredtoImmobilon-Pmembraneandimmunoblottedwith0.5μg/mLmouseanti-SOD2asdescribedinProtocolonDatasheet.A10secondexposuretofilmisshown.
SOD2is,however,wellconservedfromspeciestospeciesandshares90%and87%homologywithmouseandratSOD2.Oxidativestresshasbeenimplicatedinmanydiseasesandthechiefsourceofreactiveoxygenspecieswithinthecellisthemitochondrion.SOD2isafreeradicalscavengingenzymethatprotectsagainstdamagefromsuperoxideproducedasabyproductofoxidativephosphorylation.SOD2isrequiredfornormalBIOLOGicfunctionoftissuesbymaintainingtheintegrityofmitochondrialenzymessusceptIBLetoinactivationbysuperoxide.Mutationsinthisgenehavebeenassociatedwithidiopathiccardiomyopathy(IDC),prematureaging,sporadicmotorneurondisease,andcancer.
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