Type:RabbitIgG
Applications:IHC;WB;E
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:B;Ch;H;M;P;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Syntheticpeptide-Aminoacids417-425ofhumanSMAD3protein.Immunogenmodification:pSer423/425
Smad3 (alsoknownasMothersagainstdecapentaplegichomolog3MothersagainstDPPhomolog3,Mad3,hMAD-3,JV15-2orhSMAD3)isa50kDamemberofafamilyofproteinsthatactaskeymediatorsofTGFbetasuperfamilysignalingincellproliferation,differentiationanddevelopment.TheSmadfamilyisdividedintothreesubclasses:receptorregulatedSmads,activin/TGFbetareceptorregulated(Smad2and3)orBMPreceptorregulated(Smad1,5,and8);thecommonpartner,(Smad4)thatfunctionsviaitsinteractiontothevariousSmads;andtheinhibitorySmads,(Smad6and7).ActivatedSmad3oligomerizeswithSmad4uponTGFbetastimulationandtranslocatesasacomplexintothenucleus,allowingitsbindingtoDNAandtranscriptionfactors.PhosphorylationofthetwoTGFbetadependentserines423and425intheCterminusofSmad3iscriticalforSmad3transcriptionalactivityandTGFbetasignaling.
Image:Paraffin-embeddedtissuesectionsofhuman skinstainedwithanti-Smad3.
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