Type:MouseIgG
Applications:E;ICC;IF;IP;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R;Rb
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:N-terminal,extracellularregionofhumanCalciumSensingReceptor.[UniProt#P41180].
CalciumSensingReceptor(CaSR)wasthefirstGPCRidentifiedwhosemainphysiologicalligandisanionandithastheABIlitytosenseextracellularconcentrationofCa2+.CaSR"sactivityismediatedbyaG-proteinthatactivatesaphosphatidylinositol-calciumsecondmessengersystemanditiscapableofinteractionwithVCP,RNF19A(executeCASR"subiquitination)andARRB1.CaSRisexpressedprimarilyinchiefcellsofparathyroidglandswhere,whenactivatedbyhighCa2+concentrations,itdecreasesPTHrelease(calcium-retaininghormone)tomaintainCa2+.Alternatively,underhypocalcemiaconditions,CaSRisinactiveandPTHisreleasedwhichrestoresnormocalcemiabyactingonkidneyaswellasintestinetoincreaseCa2+absorption,andonbone,tomobiliseskeletalCa2+.
Image:WesternBlotofCalciumSensingReceptorintransfected293celllysate.ECLexposure,5minutes.Inthisphoto,theproteinhasaggregatedandthusthehigherMWbandasexpected.
CaSRisalsoexpressedinothertissueswhichdonotplayanobviousroleinCa2+homeostasis(breast,bloodvessels,liver,andplacenta)andalteredCaSRexpressionand/oractivityhavebeenfoundassociatedwithparathyroidglandsdisorders,osteoporosis,vascularcalcificationandcancer.CaSRisimplicatedinregulationofdiverseprocessesthatincludeshormonesecretion,geneexpression,ionchannelactivity,modulationofinflammation,proliferation,differentiation,andapoptosis,dependingoncelltype,andtherefore,representsakeymoleculeinphysiology.DefectsinCaSRhavebeenlinkedtofamilialhypocalciurichypercalcemiatype1(FHH),neonatalsevereprimaryhyperparathyroidism(NSHPT),familialisolatedhypoparathyroidism(FIH)andepilepsy,idiopathicgeneralizedtype8(EIG8).
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