Type:MouseIgG
Applications:FC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllImmunogen:Clone#:28126
CD130,alsoknownasgp130,isatypeItransmembranesignalingmoleculeof130-140kDathatisfoundoncellsurfacesusuallyassociatedwiththespecificreceptorchainsforthefollowingcytokines:IL-6,IL-11,leukemiainhibitoryfactor(LIF),OncostatinM,ciliaryneurotrophicfactor(CNTF)andcardiotrophin-1(CT-1)(1).TheoverlapofBIOLOGicalactivityofthesecytokinesisproofofthecommonrolethatgp130/CD130playsinthesignalingcascadeforthesemolecules.Theextracellularstructureofgp130/CD130iscomposedofsixfibronectintypeIIImodules.Asolubleformofgp130/CD130existsinserumandcanactasanantagoNISTformoleculesthatinteractwithgp130/CD130.CD130hasnointrinsickinaseactivity,however,itdoesappeartopossesssomeimportantbiologicalpropertiesthatrequireitspresenceduringtheearlystagesontogeny.Micethathaveamutatedgp130genesurviveonlyafewweekslargelyduetomyocardialmalformations(2).TheCD130moleculeformshomodimersinthepresenceofIL-6andIL-11receptors(3,4).Incontrast,CD130formsheterodimerswhenpresentwithLIFR,OSMR,CNTFRandCT-1R(5).AlthoughCD130doesnotappeartodirectlybindthesecytokines(OSMbeingtheonlyexception),itspresenceinconjunctionwiththecytokinespecificreceptorchainimpartshighaffinitybindingcharacteristicstothereceptors. MostcellsexpressCD130,however,theligandspecificreceptorsassociatedwithCD130displayamuchmorerestrictedcellularexpressionpatternultimatelydeterminingthecytokine-specificresponse.
References
MoreLinks:
antibodies gp130/CD130-Goat gp130/CD130-MouseMonoclonal IL-6(Mouse) IL-6(Rat) LIF,human LIF,mouse CDandCellSurfaceMarkerAntibodies IL,CCR,CXC,MIPandSTATAntibodies ImmuneResponseResearchAntibodies PainandInflammationResearchAntibodies proteins: IL-6_human IL-6-mouse IL-6,Human,histagged LeukemiaInhibitoryFactor(LIF),glycosylated,human LeukemiaInhibitoryFactor(LIF),mouse LeukemiaInhibitoryFactor(LIF),rat CDAntigenProteins ILs/CXCLs-RelatedCytokine&ChemokineProteins ImmuneResponseResearchProteins PrimaryNeuronsandAstrocytes-Primaryhuman,ratandmouseneuronsandastrocytes StemCellResearchReagents
Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。
Neuromics因为是由一批顶尖的学术和商业实验室挑选，试验和创新他们的 试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从 以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。
本网站将在规定时间内给予删除等相关处理。
