CD130,alsoknownasgp130,isatypeItransmembranesignalingmoleculeof130-140kDathatisfoundoncellsurfacesusuallyassociatedwiththespecificreceptorchainsforthefollowingcytokines:IL-6,IL-11,leukemiainhibitoryfactor(LIF),OncostatinM,ciliaryneurotrophicfactor(CNTF)andcardiotrophin-1(CT-1)(1).TheoverlapofBIOLOGicalactivityofthesecytokinesisproofofthecommonrolethatgp130/CD130playsinthesignalingcascadeforthesemolecules.Theextracellularstructureofgp130/CD130iscomposedofsixfibronectintypeIIImodules.Asolubleformofgp130/CD130existsinserumandcanactasanantagoNISTformoleculesthatinteractwithgp130/CD130.CD130hasnointrinsickinaseactivity,however,itdoesappeartopossesssomeimportantbiologicalpropertiesthatrequireitspresenceduringtheearlystagesontogeny.Micethathaveamutatedgp130genesurviveonlyafewweekslargelyduetomyocardialmalformations(2).TheCD130moleculeformshomodimersinthepresenceofIL-6andIL-11receptors(3,4).Incontrast,CD130formsheterodimerswhenpresentwithLIFR,OSMR,CNTFRandCT-1R(5).AlthoughCD130doesnotappeartodirectlybindthesecytokines(OSMbeingtheonlyexception),itspresenceinconjunctionwiththecytokinespecificreceptorchainimpartshighaffinitybindingcharacteristicstothereceptors. MostcellsexpressCD130,however,theligandspecificreceptorsassociatedwithCD130displayamuchmorerestrictedcellularexpressionpatternultimatelydeterminingthecytokine-specificresponse.
References
antibodies gp130/CD130-Goat gp130/CD130-MouseMonoclonal IL-6(Mouse) IL-6(Rat) LIF,human LIF,mouse CDandCellSurfaceMarkerAntibodies IL,CCR,CXC,MIPandSTATAntibodies ImmuneResponseResearchAntibodies PainandInflammationResearchAntibodies proteins: IL-6_human IL-6-mouse IL-6,Human,histagged LeukemiaInhibitoryFactor(LIF),glycosylated,human LeukemiaInhibitoryFactor(LIF),mouse LeukemiaInhibitoryFactor(LIF),rat CDAntigenProteins ILs/CXCLs-RelatedCytokine&ChemokineProteins ImmuneResponseResearchProteins PrimaryNeuronsandAstrocytes-Primaryhuman,ratandmouseneuronsandastrocytes StemCellResearchReagents
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