PDGFisoformsexerttheircellulareffectbybindingtothestructurallysimilarreceptortyrosinekinases(RTKs),PDGFRalphaandPDGFRbeta.PDGF-AA,PDGF-BB,PDGF-CC,PDGF-DDandPDGF-ABisofomsbindthetwodistinctcellsurfacePDGFreceptorswithdifferentaffinities.BothPDGFRalphaandPDGFRbetaaremembersoftheclassIIIsubfamilyofreceptortyrosinekinases(RTK).AllclassIIIRTKsarecharacterizedbythepresenceoffiveimmunoglobulin-likedomainsintheirextracellularregionandasplitkinasedomainintheirintracellularregion.PDGFbindinginducesreceptorhomo-andheterodimerizationleADIngtosignaltransduction.Theexpressionofalphaandbetareceptorsareindependentlyregulatedinvariouscelltypes.
Image: PDGF StaininginRαincryostattissuesectionsofmouseembryo(13d.p.c.)using15µg/mLofPDGFRAlpha.Tissueswerestainedusing HRP-DAB(red-brown)andcounterstainedwithhematoxylin(blue).
PDGFhasalsobeenlinkedtoatherosclerosis,fibrosisandmalignantdiseases.
PDGFRAlpha/CD140ACustomerPublications-(forstainingofOligodendrocyteLineage(OL)Cellssee10.1016/j.ajpath.2011.09.018.
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