Type:GoatIgG
Applications:ICC;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:E.colicoliderivedrecombinanthumanZIC1Met1-Gly198.
ZIC1orZincfingerproteinZIC1isamemberoftheZICfamilyofC2H2-typezincfingerproteins.Theseproteinsareparticularlyimportantduringembryonicdevelopment.ZIC1isatranscriptionalactivatorviainteractionwithGLI1,GLI2,andGLI3.ZIC1facilitatesdevelopmentandmaturationofthecerebellumandspinalcordduringorganogenesisoftheCNS.Withinthepontinegraynucleus(PGN)ZIC1playsaroleinspatialdistributionofmossyfiberneurons.TheinteractionbetweenZicandGlifamilyproteinsaresignificantformolecularantagoNISTicandsynergisticfactorsindevelopment.
Images:ZIC1stainingofimmersionfixedfrozensectionsofmousebrain(cerebellum)using15µg/mLofAntibodyovernightat4°C.TissuewasstainedwiththeAnti-GoatHRP-DABandcounterstainedwithhematoxylin(blue).Protocolondata-sheet.
ThisproteinismainlyfoundwithintheCNSandhashighlevelsofexpressioninthecerebellum.Incanceroustissue,theZIC1proteinisoftenfoundinmedulloblastomas.ZIC1hasbeenusedasaneuroepithelialMarker.
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