ERK1andERK2(alsoknownasMAPK3andMAPK1)are44-and42-kDaSer/Thrkinases,respectively.TheyarepartoftheRas-Raf-ERKsignaltransductioncascadeoftenfounddownstreamofgrowthfactorreceptoractivation.ERK1andERK2wereinitiallyisolatedandclonedaskinasesactivatedinresponsetoinsulinandNGF.Theyareexpressedinmost,ifnotall,mammaliantissues.DualthreonineandtyrosinephosphorylationactivatebothERKs,atThr202/Tyr204forhumanERK1andThr185/Tyr187forhumanERK2.
ERK1isinvolvedinvariouscellularproliferation,differentiation,andcellcycleprogressioninresponsetoavarietyofextracellularsignalsmakingitusefulforthestudyofprocesseslikeangiogenesis,neurogenesisandtumOrigenesis.TheactivationofERKbyproinflammatorystimulimayplayimportantrolesininnateimmuneresponsesandautoimmunity.
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