GABAAreceptorsareligand-gatedchloridechannelsthatplayaroleasinhibitoryneurotransmitters.Theyareknowntargetsforcertainclassesofenvironmentalandpharmaceuticalcompounds, becauseanumberofdrugsinteractwithbindingsitesonGABA(A).Someofthesedrugsincludebenzodiazepines,anticonvulsants,andanesthetics.
Image:GABAAReceptor,deltastainingofculturedrathippocampalneuronsurface(S,left)andtotalprotein(T,right)DatacourtesyofSuchitraJoshiandJaideepKapur,UniversityofVirginia.
TheGABA-Areceptorisgenerallypentamericandtherearefivetypesofsubunits:alpha,beta,gamma,delta,andrho.(GenomeRes.16(1):55–65).DefectsinGABAAR,delta (GABRD) geneare associatedAtaxiandGeneralized Epilepsy.
ThisantibodyhasbeendevelopedbyUCDavisunderagrantbyNIH.
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