Type:MouseIgG
Applications:FC;IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:ProteinGPurified-liquid
Immunogen:ThisantibodywasproducedfromamousehybridomaelicitedfromaBalb/cmouseinoculatedwithhumanCCR6transfected,NS0mousemyelomacells.
Chemokinereceptorsareseven-transmembranedomainG-proteincoupledreceptorsthatmediatetheBIOLOGicalactivitiesofchemokines.Mostofthesereceptorsexhibitpromiscuousbindingpropertieswherebyseveraldifferentchemokinessignalthroughthesamereceptor.Theyarenamedaccordingtothechemokinesubfamilytheybind.TherearecurrentlyelevenCC-specificreceptorsdesignatedCCR1toCCR11.
Image:CCR6Stainingofhumanspleen.CellswerestainedusingABC-HRP+AECandHaematoxylin(blue).
ThisreceptorhasbeenshowntobeimportantforBlineagematurationandantigendrivenBcelldifferentiation,anditmayregulatethemigrationandrecruitmentofdentriticandTcellsduringinflammatoryandimmunologicalresponses.
CCR6hasbeenreportedtobeexpressedinintestine,colon,liver,lymphnode,spleen,lung,blood,umbilicalcord,placenta,skin,andpancreas.Ithasalsobeenreportedtobeexpressedinlymphocytes,Tcells,andBcells.
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