N-methyl-D-aspartatereceptor(NMDAR)formsaheterodimerofatleastoneNR1andoneNR2A-Dsubunit.MultiplereceptorisoformswithdistinctbraindistributionsandfunctionalpropertiesarisebyselectivesplicingoftheNR1transcriptsanddifferentialexpressionoftheNR2subunits.NR1subunitsbindtheco-agoNISTglycineandNR2subunitsbindtheneurotransmitterglutamate.
NMDAreceptorsareamongthemoststudiedreceptorsinneurosciencebecausetheyareinvolvedinneuronalcelldevelopmentandplasticity,acellularcorrelateforlearning.NMDAreceptorsarealsoimplicatedinseveraldisordersofthecentralnervoussystemincludingepilepsyandischemicneuronalcelldeath.NMDAreceptorsalsoappeartobeatargetforethanolatphysiologicalconcentrationsandthereforemayplayasignificantroleinalcoholism.
Image:NMDAR2AWesternBlotAnalysis:
Lane1:RatHippocampus
Lane2:HEKcellstransfectedwithNMDANR2A
Lane3:HEKcellstransfectedwithNMDANR2B
Lane4:HEKcellstransfectedwithNMDANR2C
Lane5:sameasLane2butantibodypreabsorbedwithNMDANR2A
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