Type:GoatIgG
Applications:E;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Purified,NS0-derived,recombinanthumanJagged1(rhJagged1)extracellulardomain.
MammalianJaggedproteinsarehomologsoftheDrosophilaNotchligand,Serrate,andtogetherwithDelta-likeproteins,constituteligandsforthemammalianNotchproteins.Jagged1and2are180kDaand150kDatypeItransmembraneglycoproteins,respectively,thatpossessextracellularDSL(delta,serrate,lag-2consensussequence)domainsnecessaryforbindingtoNotchreceptors,alongwith15-16calcium-bindingEGF-likerepeatswhichmodulatethebindingaffinity.Jagged-Notchsignalingspecifiescellfate,regulatespatternformation,definesboundariesbetweendifferentcelltypes,andmodulatescellproliferationanddifferentiation,especiallyduringhematopoiesis,myogenesis,neurogenesisanddevelopmentofthevasculature.Sinceboththeligandsandreceptorsaretransmembraneproteins,directcell-cellinteractionsarethoughttoberequiredforfunctionalNotchsignaling.
Image:Jagged1stainingofparaffin-embeddedhumankidneycancer.HRP-DABreagents(browncolor)wereusedforthedetectionand counterstainedusinghematoxylin(blue).
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