Neuromics/Tar DNA Binding Protein 43 (TDP43)/MO22117/100 ul,Neuromics,,Neuromics,Neuromics INC,+,,Array.Array.Array蚂蚁淘厂家直采.

产品名称：Neuromics/Tar DNA Binding Protein 43 (TDP43)/MO22117/100 ul

产品编号：MO22117

市场价：¥4500.00

场地：美国(厂家直采)

产品分类：抗体类>一抗>功能性抗体>

联系QQ：1570468124

电话号码：4000-520-616

邮箱： info@ebiomall.com

美元价：$225.00

品牌： Neuromics

公司：Neuromics

公司分类：

商品介绍

Type:MouseIgG

Applications:IF;WB

E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssays

SpeciesReactivity:B;H;M;P;R

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

Format:AscitesFluid-liquid

Immunogen:FulllengthrecombinanthumanTDP43expressedinandpurifiedfromE.coli.

TarDNABindingProtein,TDP43orTARDBPwasoriginallyidentifiedasatranscriptionalrepressorthatbindstochromosomallyintegratedTARDNAandrepressesHIV-1transcription.ItwasalsoreportedtoregulatealternatesplicingoftheCFTRgeneandtheapoA-IIgene.

Image:TDP43stainingofformalinfixedadultratbrain,specificallythehippocampus.Hippocampalneuronnucleiarestainedstrongly.ChickenantibodytoGFAP(green)showstheprocessesofastrocyticglialcells.NucleiofallcellsarerevealedwithDAPIDNAstain(blue).TheTARDPantibodystainsneuronalnucleistronglyandthenucleiofsomenon-neuronalcellsmuchmoreweakly.Neuronalnucleithereforelookcrimson,sincetheyarebothredduetothecontentofTDP43andblueduetotheircontentofDNA,stainedbluewithDAPI.Protocolondata-sheet.

Lateritwasdiscoveredthathyper-phosphorylated,ubiquitinatedandcleavedformofTARDBP,knownaspathologicTDP43,isthemajordiseaseproteininubiquitin-positive,tau-,andalpha-synuclein-negativefrontotemporaldementia(FTLD-U)andinAmyotrophiclateralsclerosis(ALS).ElevatedlevelsoftheTDP-43proteinhavealsobeenidentifiedinindividualsdiagnosedwithchronictraumaticencephalopathy,aconditionthatoftenmimicsALSandthathasbeenassociatedwithathleteswhohaveexperiencedmultipleconcussionsandothertypesofheadinjury.

品牌介绍

Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。

Neuromics因为是由一批顶尖的学术和商业实验室挑选，试验和创新他们的试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。

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