NeurotensinReceptor3,also knownasSortilin, isamemberofthefamilyofVps10p-domainreceptors,andisfoundexpressedinbrain,spinalcordandmuscle. NTS3 isexpressedduringembryogenesisinareaswherenervegrowthfactor(NGF)anditsprecursor,proNGF,havewell-characterizedeffects.
Image:NTS3stainingofratbrain(cortex)-Dilution-1:1000
ItisrequiredforproteintransportfromtheGolgiapparatustothelysosomesbyapathwaythatisindependentofthemannose-6-phosphatereceptor(M6PR).AlsorequiredforproteintransportfromtheGolgiapparatustotheendosomes.PromotesneuronalapoptosisbymediatingendocytosisoftheproapoptoticprecursorformsofBDNF(proBDNF)andNGFB(proNGFB).Alsoactsasareceptorforneurotensin.MaypromotemineralizationoftheextracellularmatrixduringosteogenicdifferentiationbyscavengingextracellularLPL.ProbablyrequiredinADIpocytesfortheformationofspecializedstoragevesiclescontainingtheglucosetransporterSLC2A4/GLUT4(GLUT4storagevesicles,orGSVs).ThesevesiclesprovideastablepoolofSLC2A4andconferincreasedresponsivenesstoinsulin.MayalsomediatetransportfromtheendoplasmicreticulumtotheGolgi.
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