Type:RabbitIgG
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:Pr;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-lyophilized
Immunogen:YPFFconjugatedtoBSA
Endomorphinsarerecentlydiscoveredendogenousopioidpeptidescomposedoffouraminoacids:Endomorphin-1(EM-1)isTyr-Pro-Trp-Phe-NH2,and Endomorphin-2(EM-2)isTyr-Pro-Phe-Phe-NH2.Thesepeptideshaveaveryhighaffinityandspecificityformu-opioidreceptorsasithasbeenreportedinmanypharmacologicalstudies.EM-1isdistributedinmanybrainregions,whereasEM-2isprevalentinbrainstemandspinalcord. EM-1andEM-2exerttheirantinociceptiveactivitybyinteractingwithmu-opioidreceptors.EM-1anfEM-2bindwithmu-opioidreceptorwithhighaffinityandselectivityincomparisonwithbindingtoopioiddeltaandkappareceptors.EM-1andEM-2tetrapeptidesactivateG-proteinsandinhibitadenylylcyclaseactivitywhenbindtomu-opioidreceptors.
Image:Endomorphin-2Staininginratdorsalhorn.
Note:Ouraffinity-purifiedantiEND-1antibody labelneuronalfibersinvariousbrainregionsincluding(butnotlimitedto)thalamicnuclei,periaqueductalgraymatter,amygdala,locuscoeruleus,nucleusaccumbens,parabrachialnucleus,nucleustractussolitariusandseptum.Ouraffinity-purifiedanti EM-2antibodieslabelneuronalprocessesinspinalcorddorsalhornandtrigeminaltract,andlabelneuronalcellbodiesinthalamus. END-1and2 distributioninbrainoverlapswithmu-opioidreceptors.
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