Type:RabbitIgG
Applications:IHC
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:(C)KASRWRGRQNREKR
Alpha2A,2B,and2CadrenergicreceptorsareseventransmembranereceptorsthatcoupletoinhibitoryG-proteins.Alpha2ChasawidedistributionpatternintheCNS.
Onneurons,Alpha 2adrenergicreceptors(alpha2ARs)arelocatedonbothpre-andpostsynapticdomainswheretheymediateaninhibitoryroleinthecentralandperipheralnervoussystem.Alpha2ChasawidedistributionpatternintheCNS.Atthespinalcordlevelthevastmajorityofalpha2Cisnotofprimaryafferentorigin;however,asmallfractionofneuronsinDRGdoexpressmRNAforalpha2Candharbortheprotein.Colocalizationhasbeenobservedbetweenalpha2Candenkephalininthespinalcorddorsalhorn,spinalcordinterneuronsandα-motoneurons.Thedistributionpatternofalpha2Csuggestsfunctionsatseverallevelsinthebrain.Antibodyshowedpositivestaininginratspinalcorddorsalhorn,ventralhornmotorneuronsandretina.
Image:Alpha 2adrenergicreceptorlabelinginratcryostatsectionofratbrain.Labelingisconfinedtosynapticboutons(red).TissuenucleiwerecounterstasinedwithDAPI(blue).
A2A:CustomerPublications
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