Type:MouseIgG
Applications:ICC;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Syntheticpeptideaminoacids859-875(N-terminus)ofratCav1.3(alsoknownasvoltage-dependentL-typecalciumchannelsubunitalpha-1D,RATbrainclassDandRBD,accessionnumberP27732).
Cav1.3Ca2+channelorCACN4 encodesanalpha-1subunitofavoltage-dependentcalciumchannel.Calciumchannelsmediatetheinfluxofcalciumionsintothecelluponmembranepolarization.Cav1.3voltage-gatedL-typecalciumchannels(LTCCs)translatesound-induceddepolarizationintoneurotransmitterreleaseinauditoryhaircellsandcontroldiastolicdepolarization
Image:Cav1.3Ca2+channelstainingofadultrathippocampus.
ThesechannelsalsoplayamajorroleinthegenerationofcardiacpacemakeractivitybycontributingtodiastolicdepolarizationinSANpacemakercells.GeneticknockoutorpharmacologicalinhibitionofCav1.3revertsthisdependencybacktoHCNandprotectstheseneuronsinmousemodelsofParkinson’sdiseaseinadultmice.
Note:AntibodyhasbeendevelopedbyUCDavisunderagrantbyNIH.
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