Type:MouseIgG
Applications:IF;IHC;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:H;M;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
Immunogen:Fusionproteinaminoacids1-59(cytoplasmicN-terminus)ofhumanKv7.2orKCNQ2K+channel(accessionnumberO43526).
Voltage-gatedK+channelsareimportantdeterminantsofneuronalmembraneexcitABIlity.Moreover,differencesinK+channelexpressionpatternsanddensitiescontributetothevariationsinactionpotentialwaveformsandrepetitivefiringpatternsevidentindifferentneuronalcelltypes(Maletic-Savaticetal.,1995;Pongs,1999;BlaineandRibera,1998;BurgerandRibera,1996).Kv7.2/KCNQK+channelsassociatewithKv7.3/KCNQ3K+channlestoformapotassiumchannelwithessentiallyidenticalpropertiestothechannelunderlyingthenativeM-current,aslowlyactivatinganddeactivatingpotassiumconductancewhichplaysacriticalroleindeterminingthesubthresholdelectricalexcitabilityofneuronsaswellastheresponsivenesstosynapticinputs.
Images:Kv7.2(dilution1:100)stainingofratskinslicedinto40μmcryo-sections(red)andcounterstainedwithNF-H(green)doi:10.3389/fnmol.2012.00063.
Defectsin Kv7.2arethecauseofbenignfamilialneonatalseizurestype1(BFNS1). Itisalsoexpressedintheperipheralterminalsofnociceptiveprimaryafferents.
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