Type:MouseIgG
Applications:IF;WB
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:B;H;M;P;R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:AffinityPurified-liquid
RhodopsinistheproteininthemammalianretinaresponsIBLeforthelightsensitivityofrodcells,whichareresponsibleforvisioninlowlightlevels.TherhodopsinproteinisamemberoftheGprotein-coupledreceptor(GPCR)rhodopsin-likefamily.Itexistswithatheligandboundsubsatncenamedretinal.Retinalcanexistintwoisomericforms,11-cisand11-transretinal.Inthedarkrhodopsinisassociatedwith11-cisretinal,butlightcauseathe11-cisformtofliptothe11-transform,andthiscausesanalterationinthestructureoftherhodopsinmakingitcatalyticallyactiveresultinginareducedrateofphotoreceptorsynapticrelease.Activityisshutoffbyphosphorylationundertheinfluenceofrhodopsinkinase,theactivityofwhichresultsinbindingofvisualarrestin(a.k.a.arrestin-1andS-antigen),whichpreventsrhodopsinfrominteractingwithandactivatingmoretransducinmolecules.
Image:Rhodopsinstainingofpigretinalsections(green)andcounter-stainedwithNF-M(red)andDNA(blue).Rhodopsinismostabundantintheoutersegmentsofretina(OS),NF-Misabundantintheopticnervefiberlayer(ONFL),butseeninprocessesandneuronsinotherregionsalso.Otherlayersarepigmentedepithelium(PE),outerandinnernuclearlayers(ONL,INL),outerandinnerplexiformlayers(OPL,IPL)andganglioncelllayer(GCL).Protocolondata-sheet.
DefectsinRhodopsinarethecauseofretinitispigmentosatype4.Patientstypicallyhavenightvisionblindnessandlossofmidperipheralvisualfield.Astheirconditionprogresses,theylosetheirfarperipheralvisualfieldandeventuallycentralvisionaswell.
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