Type:Protein
SpeciesReactivity:R
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllGlialCellLine-derivedNeurotrophicFactor(GDNF)isarecentlydiscoveredneurotrophicfactorthathasbeenshowntopromotethesurvivalofvariousneuronalsubpopulationsinboththecentralaswellastheperipheralnervoussystemsatdifferentstagesoftheirdevelopment.NeuronalsubpopulationsthathavebeenshowntobeaffectedbyGDNFincludemotoneurons,midbraindopaminergicneurons,Purkinjecellsandsympatheticneurons.
NativeGDNF,adisulfide-linkedhomodimericglycoprotein,isanovelmemberoftheTGF-βsuperfamily.RatGDNFCDNAencodesa211aminoacidresidueprepropeptidethatisprocessedtoyieldadimericproteincomposedoftwo134aminoacidresiduesubunits.TheGDNFsequencecontainstwopotentialglycosylationsitesandinsectcell-expressedrecombinantratGDNFproteinsareglycosylated.MatureratandhumanGDNFexhibitapproximately93%aminoacidsequenceidentityandshowconsiderablespeciescross-reactivity.CellsknowntoexpressGDNFincludeSertolicells,type1astrocytes,Schwanncells,neurons,pinealocytesandskeletalmusclecells.
Reference:
ADNAsequenceencodingtheratGDNFproteinsequence(Lin,L-F.etal1993,Science260:1130-1132)wasinsertedinabaculovirusexpressionvectorandexpressedinSf21insectcells.
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