Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllOsteoprotegerin,whichisamemberofthetumornecrosisfactorreceptorsuperfamilyandisinvolvedintheregulationofbonemetabolism.OPGanditsligand(OPGL)arecytokinesregulatingosteoclasto-genesis.OPGLbindstoreceptorsonthesurfaceofpreosteoclastsandstimulatestheirdifferentiationintoactiveosteoclasts.Thisleadstoosteoresorption.OPGinhibitsthisosteoclasto-genesis(OPGissecretedbyosteoblasts,andbindstoOPGL,thusinhibitingmaturationofosteoclastsandosteoresorption).ThedegreeandactivityofosteoresorptiondependmainlyonthebalancebetweenOPGanditsligand(OPGL);factorsincreasingOPGLexpressionmostlyreduceOPGexpressionandviceversa.
Reference:
1.Effectsofhypolipemicdrugsontheosteoprotegerin-sRANKLsysteminpatientswithcoronaryarterydisease. ThrombHaemost2007May;97(5):868-70
2.Plasmaosteoprotegerinlevelsinthegeneralpopulation:relationtoindicesofleftventricularstructureandfunction. Hypertension2007Jun;49(6):1392-8
3.Thesex-specificassociationofserumosteoprotegerinandreceptoractivatorofnuclearfactorkappaBlegendwithbonemineraldensityinolderadults:theRanchoBernardostudy. EurJEndocrinol2007May;156(5):555-62
4.Thyroidhormonedeficiencyandpostmenopausalstatusindependentlyincreaseserumosteoprotegerinconcentrationsinwomen. EurJEndocrinol2007May;156(5):539-45
5.Abnormalboneremodelingprocessisduetoanimbalanceinthereceptoractivatorofnuclearfactor-kappaBligand(RANKL)/osteoprotegerin(OPG)axisinpatientswithsolidtumorsmetastatictotheskeleton.
ActaOncol2007;46(2):221-9
6.Inhibitionoftoothmovementbyosteoprotegerinvs.pamidronateunderconditionsofconstantorthodonticforce. EurJOralSci2007Apr;115(2):131-6
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