Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllPleiotrophin(Osteoblast-SpecificFactor-1,OSF-1)contains136aminoacidresidues.Thesequenceisveryrichincationicaminoacids(24%oftheresidues);lysineclustersequencesarefoundintheN-terminalandC-terminalendsofthestructure.
TheOSF-1genewasshownbyNorthernblottinganalysistobeexpressedinmousecalvarialosteoblast-enrichedcellsandinmousebraintissues,butnotinthymus,spleen,kidney,liver,lung,testisorheart.PleiotrophinhastheABIlitytopromoteadhesion,migration,expansion,anddifferentiationofhumanosteoProgenitorcells.Inadditiontocertaintypesofcancer,theembryonicgrowthanddifferentiationfactorpleiotrophinisfoundalsoinadultsininflammatorydiseases.Inosteoarthritis,pleiotrophinisespeciallyexpressedinearlystages,anditsconcentrationsinthesynovialfluidcouldserveasaMarkerfortheprogressofthedisease.Pleitrophinmightbeinvolvedincartilagerepairinosteoarthritis,inparticular,inearlierstages.
References:
•UlbrichtU,BrockmannMA,AignerA,EckerichC,MullerS,FillbrandtR,WestphalM,LamszusK.Expressionandfunctionofthereceptorproteintyrosinephosphatasezetaanditsligandpleiotrophininhumanastrocytomas.JNeuropatholExpNeurol.2003Dec;62(12):1265-75.
•HidaH,JungCG,WuCZ,KimHJ,KodamaY,MasudaT,NishinoH.Pleiotrophinexhibitsatrophiceffectonsurvivalofdopaminergicneuronsinvitro.EurJNeurosci.2003May;17(10):2127-34.
•PufeT,BartscherM,PetersenW,TillmannB,MentleinR.Pleiotrophin,anembryonicdifferentiationandgrowthfactor,isexpressedinosteoarthritis.OsteoarthritisCartilage.2003Apr;11(4):260-4.
•PufeT,BartscherM,PetersenW,TillmannB,MentleinR.Expressionofpleiotrophin,anembryonicgrowthanddifferentiationfactor,inrheumatoidarthritis.ArthritisRheum.2003Mar;48(3):660-7.
•MuramatsuT.Midkineandpleiotrophin:tworelatedproteinsinvolvedindevelopment,survival,inflammationandtumOrigenesis.JBiochem(Tokyo).2002Sep;132(3):359-71.Review.
•DeuelTF,ZhangN,YehHJ,Silos-SantiagoI,WangZY.Pleiotrophin:acytokinewithdiversefunctionsandanovelsignalingpathway.ArchBiochemBiophys.2002Jan15;397(2):162-71.
Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。
Neuromics因为是由一批顶尖的学术和商业实验室挑选，试验和创新他们的 试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从 以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。
本网站将在规定时间内给予删除等相关处理。
