Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllCD14isanapproximately 50kDacellsurfaceglycoproteinthatispreferentiallyexpressedonmonocytes/macrophages.ThehumanCD14CDNAencodesa375aminoacid(aa)residueprecursorproteinwitha19aasignalpeptideandaC-terminalhydrophobicregioncharacteristicforglycosylphosphatidyinositol(GPI)-anchoredproteins.HumanCD14hasfourpotentialN-linkedglycosylationsitesandalsobearsO-linkedcarbohydrates.TheaminoacidsequenceofhumanCD14isapproximately65%identicalwiththemouse,rat,rabbit,andbovineproteins.CD14isapatternrecognitionreceptorthatbindslipopolysaccharides(LPS)andavarietyofligandsderivedfromdifferentmicrobialsources.ThebindingofCD14withLPSiscatalyzedbyLPS-bindingprotein(LBP).
References:
1.CD14-550C/T,whichisrelatedtotheserumlevelofsolubleCD14,isassociatedwiththedevelopmentofrespiratorysyncytialvirusbronchiolitisintheJapanesepopulation. JInfectDis2007Jun1;195(11):1618-24
2.AbsenceofsolubleCD14insalivaofyoungpatientswithdentalcaries. EurJOralSci2007Apr;115(2):93-6
3.PolymorphismsintheCD14andIL-6genesassociatedwithperiodontaldisease. JClinPeriodontol2007May;34(5):IdentificationbysurfaceplasmonresonanceofthemycobacteriallipomannanandlipoarABInomannandomainsinvolvedinbindingtoCD14andLPS-bindingprotein. FEBSLett2007Apr3;581(7):1383-90
5.Animprovedprotocolforgenerationofimmuno-potentdendriticcellsthroughdirectelectroporationofCD14+monocytes. JImmunolMethods2007Apr10;321(1-2):94-106
6.PolymorphismsofTLR4butnotCD14areassociatedwithadecreasedriskofaggressiveperiodontitis. JClinPeriodontol2007Feb;34(2):111-7
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