Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
ICAM-1(CD54)isasinglechainmembraneglycoproteinexpressedonthesurfaceofavarietyofnon-haematopoieticandhaematopoieticcelltypesandhasrolesinsignaltransduction,cellsignallingandlymphocyteadhesion.SolubleICAM-1isdetectableintheplasmaandiselevatedinpatientswithvariousinflammatoryconditions.Intercellularadhesionmolecule1(ICAM-1)isthecellularreceptorforthemajorgroupofhumanrhinovirusSEROtypes,includinghumanrhinovirus14(HRV14)andHRV16.
Image: ICAM-1structureandsequence.
References:
1.AmodelofthecomplexbetweenthePfEMP1malariaproteinandthehumanICAM-1receptor. Proteins2007Jul19;
2.ArachidonicAcidbutnotEicosapentaenoicAcid(EPA)andOleicAcidActivatesNF-kappaBandElevatesICAM-1ExpressioninCaco-2Cells. Lipids2007Aug;42(8):687-98
3.HTLV-1p12Idown-modulatesICAM-1and-2andreducesnaturalkillercelladherencetherebyprotectingHTLV-1-infectedprimaryCD4+Tcellsfromautologousnaturalkillercell-mediatedcytotoxicitydespitethereductionofmajorhistocompatibilitycomplexclassImoleculesontheinfectedcells. JVirol2007Jul3;
4.[Theinfluenceoferythropoietin(Epo)onintercellularadhesionmolecule-1(ICAM-1,CD54)andplatelet-endothelialcelladhesionmolecule-1(PECAM-1,CD31)expressiononhumanumbilicalveinendothelialcells(HUVEC)inducedbytumornecrosisfactor-alpha(TNF-alpha)] WiadLek2007;60(1-2):22-7
5.Hyaluronaninhibitscytokineproductionbylipopolysaccharide-stimulatedU937macrophagesthroughdown-regulationofNF-kappaBviaICAM-1. InflammRes2007Jun;56(6):246-53
6.Vascularcelladhesionmolecule-1(VCAM-1)andintercellularadhesionmolecule-1(ICAM-1)provideco-stimulationinpositiveselectionalongwithsurvivalofselectedthymocytes. MolImmunol2007Jun29
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