Type:Protein
Applications:AdherentCellAssays
E=ELISA;FACS;FC=FlowCytometry;FPLC=FastProteinLiquidChromatography;GF=GravityFlow;HPLC=HighPerformanceLiquidChromatography;ICC=Immunocytochemistry;IF=Immunofluorescence;IHC=Immunohistochemistry;IP=Immunoprecipitation;NAC=Non-adherentCellAssays;NB=NeutralizationofBioactivity;SE=SandwichELISA;TPE=TargetedProteinExpression;WB=Westernblotting;;AC=AdherentCellAssays;FM=FluorescentMicsroscopy;;;BSC-CM5=BiacoreSensorChipCM5;BSM=BiosactiveSmallMoleculeorPeptide;CDM=CellDifferentiationMedia;;;;;;HealthandFitness;;;DNAExtraction/Purification;;InvivoLikeAssaysSpeciesReactivity:B
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFibronectinpurifiedfrombovineplasmabyaffinitychromatographyongelatin-Sepharose.
Fibronectinisahigh-molecularweight(~440kDa)extracellularmatrixglycoproteinthatbindstomembrane-spanningreceptorproteinscalledintegrins.[1]Inadditiontointegrins,fibronectinalsobindsextracellularmatrixcomponentssuchascollagen,fibrinandheparansulfateproteoglycans(e.g.syndecans).Fibronectinexistsasadimer,consistingoftwonearlyidenticalmonomerslinkedbyapairofdisulfidebonds.Thefibronectinproteinisproducedfromasinglegene,butalternativesplicingofitspre-mRNAleadstothecreationofseveralisoforms.
MeasuredbyitsABIlitytosupportcellattachmentandspreADIngwhenusedasasubstratumforcellculture.Inthisapplication,therecommendedconcentrationforthiseffectistypically1-5μg/cm2.Fibronectincanalsobeaddedinthemediatosupportcellspreadingataconcentrationof0.5-50μg/mL.Optimalconcentrationdependsoncelltypeaswellastheapplicationorresearchobjectives.
Fibronectinplaysamajorroleincelladhesion,growth,migrationanddifferentiation,anditisimportantforprocessessuchaswoundhealingandembryonicdevelopment.Alteredfibronectinexpression,degradation,andorganizationhasbeenassociatedwithanumberofpathologies,includingcancerandfibrosis.
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