Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllFormat:liquid-liquid
HumanplasmaserumpFNisaclear,sterile,bufferedsolutionwithapHofabout7.3to7.7.
Fibronectinisahigh-molecularweight(~440kDa)extracellularmatrixglycoproteinthatbindstomembrane-spanningreceptorproteinscalledintegrins.[1]Inadditiontointegrins,fibronectinalsobindsextracellularmatrixcomponentssuchascollagen,fibrinandheparansulfateproteoglycans(e.g.syndecans).Fibronectinexistsasadimer,consistingoftwonearlyidenticalmonomerslinkedbyapairofdisulfidebonds.Thefibronectinproteinisproducedfromasinglegene,butalternativesplicingofitspre-mRNAleadstothecreationofseveralisoforms.
MeasuredbyitsABIlitytosupportcellattachmentandspreADIngwhenusedasasubstratumforcellculture.Inthisapplication,therecommendedconcentrationforthiseffectistypically1-5μg/cm2.Fibronectincanalsobeaddedinthemediatosupportcellspreadingataconcentrationof0.5-50μg/mL.Optimalconcentrationdependsoncelltypeaswellastheapplicationorresearchobjectives.
Fibronectinplaysamajorroleincelladhesion,growth,migrationanddifferentiation,anditisimportantforprocessessuchaswoundhealingandembryonicdevelopment.Alteredfibronectinexpression,degradation,andorganizationhasbeenassociatedwithanumberofpathologies,includingcancerandfibrosis.
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