Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
GCSFisacytokinethatcontrolstheproduction,differentiation,andfunctionofgranulocytes.Theactiveproteinisfoundextracellularly.Threetranscriptvariantsencodingthreedifferentisoformshavebeenfoundforthisgene.
Granulocyte/macrophagecolony-stimulatingfactorsarecytokinesthatactinhematopoiesisbycontrollingtheproduction,differentiation,andfunctionof2relatedwhitecellpopulationsoftheblood,thegranulocytesandthemonocytes-macrophages.Thiscsfinducesgranulocytes.
Image: G-CSF StructureandSequence.
References:
1.Effectsofgranulocyte-colonystimulatingfactoronperitonealdefensemechanismsandbacterialtranslocationafteradmiNISTrationofsystemicchemotherapyinrats. WorldJGastroenterol2007May14;13(18):2596-9.
2.Maygranulocytecolony-stimulatingfactorinducehypercoagulablestate? AmHeartJ2007Jun;153(6):e41.
3.Theeffectofstemcellmobilisationwithgranulocytecolony-stimulatingfactoronthemorphologyofthehaematopoieticorgansinmice. FoliaMorphol(Warsz)2007Feb;66(1):1-9.
4.Paradoxicaldropincirculatingneutrophilcountfollowinggranulocyte-colonystimulatingfactorandstemcellfactoradministrationinrhesusmacaques. ExpHematol2007Jun;35(6):872-8.
5.Pathologiccompleteresponsewithsixcomparedwiththreecyclesofneoadjuvantepirubicinplusdocetaxelandgranulocytecolony-stimulatingfactorinoperablebreastcancer:resultsofABCSG-14. JClinOncol2007May20;25(15):2012-6.Granulocytecolony-stimulatingfactorandsevereaplasticanemia. Blood2007May15;109(10):4589;authorreply4589-90.
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