Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
NeuregulinisasignalingproteinforErbB2/ErbB4receptorheterodimersonthecardiacmusclecells,playinganimportantroleinheartstructureandfunctionthroughinducingErbB2/ErbB4receptorphosphorylationandcardiomyocytedifferentiation.Researchonmolecularleveldiscoveredthatneuregulinrecombinantcouldmakedisturbedmyocardialcellstructureintoorderandstrengthentheconnectionbetweenmyocardialcellsbyintercalateddiscsre-organization.Pharmacodynamicexperimentsinanimalsshowedthatneuregulin(NRG1)recombinantcanreducethedegreeofdamageonmyocardialcellscausedbyischemia,hypoxiaandviralinfection..
References:
1.Neuregulin-1enhancesdepolarization-inducedGABArelease. Neuron2007May24;54(4):599-610.
2.Theneuregulin-1receptorerbB4controlsglutamatergicsynapsematurationandplasticity. Neuron2007May24;54(4):583-97.
3.Immunohistochemicalevidenceforimpairedneuregulin-1signalingintheprefrontalcortexinschizophreniaandinunipolardepression. AnnNYAcadSci2007Jan;1096:147-56.
4.Anacuteeffectofneuregulin1betatosuppressalpha7-containingnicotinicacetylcholinereceptorsinhippocampalinterneurons. JNeurosci2006Nov1;26(44):11295-303.
5.Neuregulin1(8p12)andchildhood-onsetschizophrenia:susceptibilityhaplotypesfordiagnosisandbraindevelopmentaltrajectories. MolPsychiatry2007Feb;12(2):195-205.
6.Neuregulin-1/erbB-activationimprovescardiacfunctionandsurvivalinmodelsofischemic,dilated,andviralcardiomyopathy. JAmCollCardiol2006Oct3;48(7):1438-47.
Image: Heregulin-B2structureandsequence
Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。
Neuromics因为是由一批顶尖的学术和商业实验室挑选，试验和创新他们的 试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从 以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。
本网站将在规定时间内给予删除等相关处理。
