Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllCT1hasalsoaneurotrophicfunction.CTF1deficiencycausesincreasedmotoneuroncelldeathinspinalcordandbrainstemnucleiofmiceduringaperiodbetweenembryonicday14andthefirstpostnatalweek.Moreover,CT-1isahepatocytesurvivalfactorthatefficientlyreduceshepatocellulardamageinanimalmodelsofacuteliverinjury.Cardiotrophin1expressionisaugmentedafterhypoxicstimulationanditcanprotectcardiaccellswhenaddedeitherpriortosimulatedischaemiaoratthetimeofreoxygenationfollowingsimulatedischaemia.Cardiotrophin1caninduceexpressionoftheprotectiveheatshockproteins(hsps)incardiaccells.
Cardiotrophin-1increasedventricularexpressionofANP,brainnatriureticpeptide(BNP)andangiotensinogenmRNA.
Cardiophin1levelsweresignificantlyelevatedinpatientswithheartfailure,patientswithdilatativecardiomyopathy,moderate/severemitralregurgitation,stableandunstableanginaandafteracutemyocardialinfarction.
Application:WesternBlot
References:
•FreedDH,MoonMC,BorowiecAM,JonesSC,ZahradkaP,DixonIM.CT-1expressioninexperimentalmyocardialinfarctionandpotentialroleinpost-MIwoundhealing.MolCellBiochem.2003Dec;254(1-2):247-56.
•FreedDH,BorowiecAM,AngelovskaT,DixonIM.Inductionofproteinsynthesisincardiacfibroblastsbycardiotrophin-1:integrationofmultiplesignalingpathways.CardiovascRes.2003Nov1;60(2):365-75.
•BristowMR,LongCS.Cardiotrophin-1inheartfailure.Circulation.2002Sep17;106(12):1430-2.
•LiaoZ,BrarBK,CaiQ,StephanouA,O"LearyRM,PennicaD,YellonDM,LatchmanDS.Cardiotrophin-1(CT-1)canprotecttheadultheartfrominjurywhenaddedbothpriortoischaemiaandatreperfusion.CardiovascRes.2002Mar;53(4):902-10.
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