Type:Protein
SpeciesReactivity:M
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllBACE-1isanasparticproteaseandanintegralmembraneprotein.Itisthemajorβsecretase,andtogetherwiththeγsecretase,isresponsIBLeforgeneratingtheamyloidβpeptide(Aβ)fromtheamyloidprecursorprotein(APP).BecauseAβisamajorcomponentofamyloidplaques,BACE-1hasbeenimplicatedintheonsetand/orprogressionofAlzheimer"sdisease.HighlevelsofBACE-1activityaresufficienttoelicitneurodegenerationandneurologicaldeclineinindicatingthatinhibitingBACE-1mayblocknotonlyAβ-dependentbutalsoAβ-independentpahtogenicmechanisms.InadditiontoAPP,BACE-1alsocleavesAPP-likeproteins1and2,thecelladhesionproteinP-selectinglycoproteinligand-1andβ-galactosideα2,6-sialyltransferase,implyingthatBACE-1mayhaveadditionalfunctionsinvolvingtheectodomainsheddingofmembraneproteins.ThepurifiedrmBACE-1correspondstotheectodomainwiththeactivitydescribedabove.
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