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主营:神经科学、干细胞以及再生医学研究试剂
℡ 4000-520-616
℡ 4000-520-616
Neuromics/Noggin/Fc Chimera, Carrier Free/PR15070CF-50/50 ug
产品编号:PR15070CF-50
市  场 价:¥6300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$315.00
品      牌: Neuromics
公      司:Neuromics
公司分类:
Neuromics/Noggin/Fc Chimera, Carrier Free/PR15070CF-50/50 ug
商品介绍

Type:Protein

 

SpeciesReactivity:H

B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All

NogginisasecretedhomodimericglycoproteinthatisanantagoNISTofbonemorphogeneticproteins(BMPs).1,2HumanNogginCDNAencodesa232aminoacid(aa)precursorprotein;cleavageofa19aasignalpeptidegeneratesthe213aamatureproteinwhichcontainsanN-terminalacidicregion,acentralbasicheparin-bindingsegmentandaC-terminalcysteine-knotstructure.2SecretedNogginprobablyremainsclosetothecellsurfaceduetoitsbindingofheparin-containingproteoglycans.3Nogginisveryhighlyconservedamongvertebrates,suchthatmaturehumanNogginshares99%,99%,98%,97%and89%aasequenceidentitywithmouse,rat,bovine,equineandchickNoggin,respectively.NogginbindssomeBMPssuchasBMP-4withhighaffinityandotherssuchasBMP-7withloweraffinity,antagonizingBMPbioactivitiesbyblockingepitopesonBMPsthatareneededforbindingtobothtypeIandtypeIIreceptors.2,4Duringembryogenesis,NogginantagonizesspecificBMPsatdefinedtimesduringneuraltube,somiteandcardiomyocytegrowthandpatterning.5-7Duringskeletaldevelopment,Nogginpreventschondrocytehyperplasia,thusallowingproperformationofjoints.4Mutationswithinthecysteine-knotregionofhumanNogginarelinkedtomultipletypesofskeletaldysplasiasthatresultinapicaljointfusions.8Nogginisexpressedindefinedareasoftheadultcentralnervoussystemandperipheraltissuessuchaslung,skeletalmuscleandskin.1Duringcultureofhumanembryonicstemcells(hESC)withoutfeederlayersorconditionedmedium,butwithadditionofFGFbasic,additionofNoggintoantagonizeBMPactivityallowshESCtomaintaintheirundifferentiated,pluripotentstate.9,10

References:

1.Valenzuela,D.M.etal.,1995,J.Neurosci.15:6077-6084.6.Itsykson,P.etal.,2005,Mol.Cell.Neurosci.30:24-36.
2.Groppe,J.etal.,2002,Nature420:636-642.7.Yuasa,S.etal.,2005,Nat.Biotechnol.23:607-611.
3.Paine-Saunders,Setal.,2002,J.Biol.Chem.277:2089-2096.8.Gong,Y.etal.,1999,Nat.Genet.21:302-304.
4.Brunet,L.J.etal.,1998,Science280:1455-1457.9.Xu,R.-H.etal.,2005,Nat.Methods2:185-190.
5.McMahon,J.A.etal.,1998,GenesDev.12:1438-1452.10.Wang,G.etal.,2005,Biochem.Biophys.Res.Commun.330:934-942.
6.Itsykson,P.etal.,2005,Mol.Cell.Neurosci.30:24-36.
7.Yuasa,S.etal.,2005,Nat.Biotechnol.23:607-611.
8.Gong,Y.etal.,1999,Nat.Genet.21:302-304.
9.Xu,R.-H.etal.,2005,Nat.Methods2:185-190.
10.Wang,G.etal.,2005,Biochem.Biophys.Res.Commun.330:934-942. 

 

品牌介绍

Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。

Neuromics因为是由一批顶尖的学术和商业实验室挑选,试验和创新他们的 试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从 以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。


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