Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllTrkA,theproductoftheproto-oncogenetrk,isamemberoftheneurotrophictyrosinekinasereceptorfamilythathasthreemembers.TrkA,TrkBandTrkCpreferentiallybindNGF,NT-4andBDNF,andNT-3,respectively.AllTrkfamilyproteinsshareaconservedcomplexsubdomainorganizationconsistingofasignalpeptide,twocysteine-richdomains,aclusterofthreeleucine-richmotifs,andtwoimmunoglobulin-likedomainsintheextracellularregion,aswellasanintracellularregionthatcontainsthetyrosinekinasedomain.TwodistinctratTrkAisoforms(TrkA-IandTrk-A-II)thatdifferbya6-aminoacidinsertionintheirextracellulardomainhavebeenidentified.ThelongerTrkAisoformistheonlyisoformexpressedwithinneuronaltissueswhereastheshorterTrkA-Iisexpressedmainlyinnon-neuronaltissues.NGFbindstoTrkAwithlowaffinityandactivatesitscytoplasmickinase,initiatingasignalingcascadethatmediatesneuronalsurvivalanddifferentiation.HigheraffinitybindingofNGFrequiresthecoexpressionofTrkAwiththep75NGFreceptor(NGFR),amemberofthetumornecrosisfactorreceptorsuperfamily.NGFRbindsallneurotrophinswithlowaffinityandmodulatesTrkactivityaswellasaltersthespecificityofTrkreceptorsfortheirligands.NGFRcanalsomediatecelldeathwhenexpressedindependentofTrk(Esposito,D.etal.,2001,J.Biol.Chem.276:32687;Sofroniew,M.V.etal.,2001,Annu.Rev.Neurosci.24:1217).
Neuromics公司提供一系列高品质新蛋白的抗体、神经干细胞及培养基、神经干细胞扩增及分化试剂盒、干细胞抗体、神经和前体细胞流式分型试剂、细胞凋亡研究试剂、荧光激活细胞分拣法试剂盒、细胞内部试剂盒、转染试剂、ELISA 缓冲稀释液与IHC-WB-ELISA 补充物等试剂。
Neuromics因为是由一批顶尖的学术和商业实验室挑选，试验和创新他们的 试剂来满足顾客的需要而使自己的表现尤为突出。Neuromics从 以上过程中获得的经验使得顾客****的实际应用和试剂独特的性能能够得以相容。它精通于提供试剂和为神经科学研究机构提供产品和服务。
本网站将在规定时间内给予删除等相关处理。
