Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
Acidicfibroblastgrowthfactorisamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofBIOLOGicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.Thisproteinfunctionsasamodifierofendothelialcellmigrationandproliferation,aswellasanangiogenicfactor.Itactsasamitogenforavarietyofmesoderm-andneuroectoderm-derivedcellsinvitro,thusisthoughttobeinvolvedinorganogenesis.
Threealternativelysplicedvariantsencodingdifferentisoformshavebeendescribed.Theheparin-bindinggrowthfactorsareangiogenicagentsinvivoandarepotentmitogensforavarietyofcelltypesinvitro.Therearedifferencesinthetissuedistributionandconcentrationofthese2growthfactors.
Image:FGF2, Sf9insectderived proteinstructureandsequence
References:
1.AcidicFGFenhancesfunctionalregenerationofadultdorsalroots.LifeSci2004Feb27;74(15):1937-43
2.LocallyreducedlevelsofacidicFGFleadtodecreasedexpressionof28-kdacalbindinandcontributetotheselectivevulnerABIlityoftheneuronsintheentorhinalcortexinAlzheimer"sdisease.Neuropathology2001Sep;21(3):203-11
3.InfluenceofIN-1antibodyandacidicFGF-fibringlueontheresponseofinjuredcorticospinaltractaxonstohumanSchwanncellgrafts. JNeurosciRes1997Dec1;50(5):888-905
4.AcidicFGFregulationofhyperproliferationoffibroblastsinhumanautosomaldominantpolycystickidneydisease. BiochemMolMed1997Aug;61(2):178-91
5.Effectofbasic(FGF-2)andacidic(FGF-1)fibroblastgrowthfactorsonearlyhaemopoieticcelldevelopment. BrJHaematol1996Jun;93(4):772-82
6.AcidicFGFinducesNGFanditsmRNAintheinjuredneocortexofadultanimals.BrainResMolBrainRes1995Oct;33(1):1-6
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