FGF-8isamemberofthefibroblastgrowthfactorfamilythatwasoriginallydiscoveredasanandrogen-inducedgrowthfactoressentialfortheandrogen-dependentgrowthofmousemammarycarcinomacells.ThemouseFGF-8primarytranscriptisalternativelysplicedtogenerateatleast7secretedisoformsthatdifferonlyattheiraminoterminis.TheFGF-8isoformsdifferentiallyactivatethevariousalternativelysplicedformsoffibroblastgrowthfactorreceptors1-3,andfibroblastgrowthfactorreceptor4.FGF-8bhasbeenshowntoactivatethe‘c’spliceformofFGFR2,FGFR3,andFGFR4.Duringmousedevelopment,expressionofFGF-8wasrestrictedtoembryonicdays9through13.ThepatternofFGF-8expressionduringmousedevelopmentsuggestsaroleforFGF-8inmultipleregionsofectodermaldifferentiationinthepost-gastrulationmouseembryo.Theseincludearoleinoutgrowthandpatterningoftheface,limbs,andcentralnervoussystemofthevertebrate.TheFGF-8locushasbeenmappedtomousechromosome19andhumanchromosome10(MacArthur,C.A.etal.,1995,Development,121:3603-3613;Crossley,P.H.etal.,1996,Cell,84:127-136).
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