Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;All
ThehumanFGF-9CDNAencodesa208aminoacidresidueproteinthatcontainsasingle,potentialN-linkedglycosylationsite.Thenativeproteinisglycosylatedandisefficientlysecretedaftersynthesis,althoughFGF-9lacksatypicalsecretionsignal.RatandmouseFGF-9showaveryhighhomologytohumanFGF-9.ThetranscriptsforFGF-9havebeenfoundinbrainandinkidneytissue.FibroblastGrowthFactor-9isamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofBIOLOGicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.FGF9wasisolatedasasecretedfactorthatexhibitsagrowth-stimulatingeffectonculturedglialcells.Innervoussystem,thisproteinisproducedmainlybyneuronsandmaybeimportantforglialcelldevelopment.ExpressionofthemousehomologofthisgenewasfoundtobedependentonSonichedgehog(Shh)signaling.Micelackingthehomologgenedisplayedamale-to-femalesexreversalphenotype,whichsuggestedaroleintesticularembryogenesisFibroblastGrowthFactor9mayhavearoleinglialcellgrowthanddifferentiationduringdevelopment,gliosisduringrepairandregenerationofbraintissueafterdamage,differentiationandsurvivalofneuronalcells,andgrowthstimulationofglialtumors.
Image:FGF-9proteinstructureandsequence
References:
1.Apolyvinylalcoholcorecoilcontainingbasicfibroblastgrowthfactorevaluatedinrabbitswithaneurysmsinducedbyelastase. Neurosurgery2007Jul;61(1):160-6
2.EffectsoflaserirrADIationonthereleaseofbasicfibroblastgrowthfactor(bFGF),insulinlikegrowthfactor-1(IGF-1),andreceptorofIGF-1(IGFBP3)fromgingivalfibroblasts. LasersMedSci2007Jul10;
3.Novelinhibitorforfibroblastgrowthfactorreceptortyrosinekinase. BioorgMedChemLett2007Jun26;
4.Anuclearexportsequencelocatedonabeta-strandinfibroblastgrowthfactor-1.JBiolChem2007Jul6;
5.Selectiveover-expressionoffibroblastgrowthfactorreceptors1and4inclinicalprostatecancer. JPathol2007Jul2;
6.Unconventionalsecretion:anextracellulartrapforexportoffibroblastgrowthfactor2. JCellSci2007Jul15;120(Pt14):2295-9
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