Type:Protein
SpeciesReactivity:H
B=Bovine;Ca=Cat;Ch=Chicken;D=Dog;EQ=Equine;GP=GuineaPig;H=Human;M=Mouse;P=Porcine;Pr=Primate;R=Rat;Rb=Rabbit;Y=Yeast;Xe=Xenopus;Ze=Zebrafish;;;;NA-NotApplicable;STP=Step-TactinProteins;AllTheterm‘PDGF’referstoafamilyofdisulphidebond-linkeddimericisoformsthatactasautocrineandparacrinegrowthfactorsandareproducedbyavarietyofcelltypesotherthanplatelets.Theyactaspotentmitogensforalmostallmesenchymally-derivedcells.
Aberrantexpressionisinvolvedincertaincancers,fibroproliferativedisordersandatherosclerosis.Theproteinalsocontributestowoundhealingandneuralregeneration.TherearefourmembersofthePDGFfamily–PDGFA,PDGFB,PDGFCandPDGFD.TwodistincttypesofPDGF-Aexist–ashortformthatissolubleandalongformthatisretainedbytheextracellularmatrix..
References:
1.Effectsofhyperbaricoxygenandplateletderivedgrowthfactoronmedialcollateralligamentfibroblasts. UnderseaHyperbMed2007May-Jun;34(3):181-90.
2.Starch-basedmicroparticlesasvehiclesforthedeliveryofactiveplatelet-derivedgrowthfactor. TissueEng2007Jun;13(6):1259-68.
3.Correlationbetweenplatelet-derivedgrowthfactorBchainandboneresorptioninratperiapicallesions. JEndod2007Jun;33(6):709-11.
4.Hepaticstellatecellprotrusionscoupleplatelet-derivedgrowthfactor-BBtochemotaxis. Hepatology2007Jun;45(6):1446-53.
5.Prognosticvalueofplatelet-derivedgrowthfactorinpatientswithseveresepsis. GrowthFactors2007Feb;25(1):15-24.
6.Endothelin1,itsendothelintypeAreceptor,connectivetissuegrowthfactor,platelet-derivedgrowthfactor,andadrenomedullinexpressioninlungsofpulmonaryhypertensiveandnonhypertensivechickens. PoultSci2007May;86(5):909-16.
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